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Transcription Factor Nrf2 Protects the Brain From Damage Produced by Intracerebral Hemorrhage
2007
Stroke
and Purpose-Intracerebral hemorrhage (ICH) remains a major medical problem for which there is no effective treatment. Oxidative and cytotoxic damage plays an important role in ICH pathogenesis and may represent a target for treatment of ICH. Recent studies have suggested that nuclear factor-erythroid 2-related factor 2 (Nrf2), a pleiotropic transcription factor, may play a key role in protecting cells from cytotoxic/oxidative damage. This study evaluated the role of Nrf2 in protecting the brain
doi:10.1161/strokeaha.107.486506
pmid:17962605
fatcat:tb6aav23rnahnbcf3c3z5jsrhq