The use of bone morphogenetic protein 7 in fracture non-unions

Sven O'hEireamhoin, John F Quinlan, Kieran O Rourke
2011 Orthopaedic Surgery  
Objective: To assess the rate of clinical and radiological union with the use of bone morphogenetic protein 7 (BMP-7) in a range of fractures. Methods: This case series retrospectively reviews a series of 16 fracture non-unions in 13 patients. These patients were treated with the commercially available BMP-7. Time to radiological and clinical union was assessed by serial out-patient follow-up. Results: At nine months post-surgery in which BMP-7 was added, 12 of 16 non-unions had achieved
more » ... l and radiographic union. Three patients required repeat grafting. The mean time to union was 5.1 Ϯ 1.6 months after the application of BMP-7. Conclusion: The use of the osteo-inductive agent, BMP-7 results in good clinical and radiological outcomes which are not restricted to tibial non-unions.
doi:10.1111/j.1757-7861.2010.00119.x pmid:22009979 fatcat:y2ivxhc22fcjrk7i4vlwt4uypq