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De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2
2020
Science
Preserved Fulltext
We developed a de novo protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracellular host proteins to infect the cell. Our pipeline allowed the design, validation, and optimization of de novo hACE2 decoys to neutralize SARS-CoV-2. The best decoy, CTC-445.2, binds with low nanomolar affinity and high specificity to the RBD of the spike protein. Cryo-EM shows that the design is accurate and can simultaneously bind to all three RBDs of a single spike
doi:10.1126/science.abe0075
pmid:33154107
pmcid:PMC7920261
fatcat:6rwvr53lhfemvagfjk74vsuroa