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CRISPR-directed mitotic recombination enables genetic mapping without crosses
Linkage and association studies have mapped thousands of genomic regions that contribute to phenotypic variation, but narrowing these regions to the underlying causal genes and variants has proven much more challenging. Resolution of genetic mapping is limited by the recombination rate. We developed a method that uses CRISPR to build mapping panels with targeted recombination events. We tested the method by generating a panel with recombination events spaced along a yeast chromosome arm,doi:10.1101/040428 fatcat:zg6pprwu2vf3tjseevmxuurzv4