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Molecular genetic findings in LRRK2 American, Canadian and German families
Journal of Neural Transmission. Supplementa
A locus for a dominant form of PD has been mapped to the pericentromeric region of chromosome 12 in a Japanese family. We have confirmed linkage in two families of European ancestry and identified mutations in the gene for LRRK2 in these two and four additional families with dominantly inherited PD. All mutations are located in highly conserved domains of the gene. The LRRK2 protein belongs to the ROCO protein family, and includes a ras domaine (ras of complex proteins) and a protein kinasedoi:10.1007/978-3-211-45295-0_35 fatcat:opojrh4ibjedtemb5sve33glqi