Amyloidosis is a rare disease characterized by the deposition of an insoluble fibrillar protein in various organs and classified into two categories: systemic and localized. In the oral and maxillofacial region, the occurrence sites of localized amyloidosis are the buccal mucosa, sublingual gland, lip, palate and tongue. We report a case of localized nodular amyloidosis in the sublingual gland and submucosa of the mouth floor. A 72-year-old woman presented a nodular mass in the left side of the

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... floor of her mouth and was referred to our hospital for further examination and treatment. Intraoral examination showed an elastic-hard, wellcircumscribed mass, covered with normal epithelium, measuring approximately 32 × 15 mm in size. The pathological diagnosis via biopsy was amyloidosis (AL amyloidosis of the Aλ type) . We diagnosed localized amyloidosis, as examination data did not support a diagnosis of systemic amyloidosis and multiple myeloma. The mass was removed surgically under general anesthesia. Seventeen months have since passed, with no sign of recurrence. Key words: localized nodular amyloidosis (限局性結節性アミロイドーシス) , sublingual gland (舌下腺) , floor of the mouth (口底) 1) 大阪大学大学院歯学研究科顎口腔疾患制御学講座 (口腔外科第一教室) (主任:田中 晋教授) 2) 大阪警察病院歯科口腔外科 (主任:石濱孝二部長)