Human endogenous retrovirus HERV-K113 is capable of producing intact viral particles

K. Boller, K. Schonfeld, S. Lischer, N. Fischer, A. Hoffmann, R. Kurth, R. R. Tonjes
2008 Journal of General Virology  
Of all human endogenous retroviruses known today, HERV-K is the only one that has been shown to produce viral particles. While the first of the approximately 30 HERV-K sequences integrated into the human genome more than 40 million years ago, evidence is accumulating that HERV-K was active more recently, provirus HERV-K113 being the youngest sequence found. However, it is unclear which HERV-K sequences code for the viral particles that are produced by human germ-cell tumours or melanomas. Here,
more » ... we show that the provirus HERV-K113, cloned into a baculovirus expression vector, is capable of producing intact particles of retroviral morphology, exhibiting the typical structure of those particles that were characterized in cell lines derived from human germ-cell tumours. Thus, the HERV-K113 sequence is a candidate for particle production in vivo and for an active human endogenous retrovirus of today.
doi:10.1099/vir.0.83534-0 pmid:18198388 fatcat:oq7xihammraupdnvyz3rnd6gv4