Pubertal testosterone influences threat-related amygdala–orbitofrontal cortex coupling

Jeffrey M. Spielberg, Erika E. Forbes, Cecile D. Ladouceur, Carol M. Worthman, Thomas M. Olino, Neal D. Ryan, Ronald E. Dahl
<span title="2014-05-01">2014</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/kqb2oz4yerdifhjgunfv4pdnoa" style="color: black;">Social Cognitive and Affective Neuroscience</a> </i> &nbsp;
Growing evidence indicates that normative pubertal maturation is associated with increased threat reactivity, and this developmental shift has been implicated in the increased rates of adolescent affective disorders. However, the neural mechanisms involved in this pubertal increase in threat reactivity remain unknown. Research in adults indicates that testosterone transiently decreases amygdala-orbitofrontal cortex (OFC) coupling. Consequently, we hypothesized that increased pubertal
more &raquo; ... e disrupts amygdala-OFC coupling, which may contribute to developmental increases in threat reactivity in some adolescents. Hypotheses were tested in a longitudinal study by examining the impact of testosterone on functional connectivity. Findings were consistent with hypotheses and advance our understanding of normative pubertal changes in neural systems instantiating affect/motivation. Finally, potential novel insights into the neurodevelopmental pathways that may contribute to adolescent vulnerability to behavioral and emotional problems are discussed. aspects of the experiments; J.M.S. performed analyses, with the assistance of T.M.O.; J.M.S. and R.E.D wrote the manuscript; all authors provided critical revisions of the manuscript.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/scan/nsu062">doi:10.1093/scan/nsu062</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24795438">pmid:24795438</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4350481/">pmcid:PMC4350481</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nnaxydq6fjfuviupuycroka2ki">fatcat:nnaxydq6fjfuviupuycroka2ki</a> </span>
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