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A Suicide-inducing Vector Carrying the Oct-4 Promoter for Eradication of the AGS Cancer Cell Line
Modares Journal of Medical Sciences: Pathobiology
Objective: In an attempt to develop safer and more effective gene therapy approaches as a realistic treatment for various forms of cancer, researchers are increasingly using tumor-specific promoters (TSP) to drive the expression of the gene of interest and eradicate cancer cells. In this study, for the first time we introduce the Oct-4 promoter as a cancer-specific promoter with a high efficacy. Methods: We cloned Oct-4 promoter and enhancers into a pGl3 control reporter vector and analyzed thefatcat:6scskyabubc3tb7iakmdpxo4ee