Aims: Preeclampsia is associated with significant maternal and perinatal morbidity and mortality, yet biomarkers for the condition have not been fully elucidated. As such, diagnosis of the condition in Ghana is based on blood pressure and urine protein measurement. the aim of this study was to compare the levels of adiponectin, leptin and the adiponectin-leptin ratio between normotensive pregnancy and preeclampsia. Materials and Methods: 60 normotensive pregnant women and 60 preeclamptic women

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... ere recruited for this case-control study. social and clinical information were obtained from all the participants. Maternal serum adiponectin and leptin were quantified using immunoassays. Differences in measured variables between groups were assessed with unpaired student's t-test; and associations among variables were described with Pearson's correlation coefficients. results: Adiponectin levels (p=0.001), leptin levels (p=0.010) and the adiponectin-leptin ratio (p=0.001) were higher in preeclampsia than in normotensive pregnancy. there was a significant inverse correlation between adiponectin and leptin in the normotensive controls (r=-0.768, p=0.002) but this relationship was attenuated in preeclampsia (r=-0.290, p=0.052). conclusion: Levels of adiponectin, leptin and the adiponectinleptin ratio were elevated in the preeclamptic women and could serve as biomarkers for the diagnosis of preeclampsia.