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Peptide mimics of a carbohydrate-associated epitope expressed by cancer cells: Identification of vaccine candidates
Molecular Medicine Reports
Cancer-associated antigen 215 (CA215) is an immunoglobulin molecule expressed by numerous tumor types. Membrane-bound and soluble CA215 have been detected in the majority of cancer cells and rarely identified in normal tissues. In addition, CA215C is a carbohydrate-associated epitope in the variable region of CA215, which is specifically recognized by the monoclonal antibody, RP215. However, CA215C is not a suitable vaccine candidate as it is a thymus-independent antigen. In the present study,doi:10.3892/mmr.2016.5863 pmid:27779668 fatcat:lgdsdori4nbzvmhjgerau73gjm