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The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway

Xueqiang Zhu, Hui Huang, Jun Zhang, Hao Liu, Rui Ao, Ming Xiao, Yuelei Wu
2017 Molecular Medicine Reports  

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The present study aimed to identify potential anticancer effects of Cucurbitacin I regulators on cell growth of human non-small cell lung cancer (NSCLC) and to explore their mechanism. The results indicated that the anticancer effects of Cucurbitacin I markedly attenuated cell proliferation, and induced apoptosis in NSCLC. Furthermore, Cucurbitacin I suppressed phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), phosphorylation (p)-AKT and p-p70S6K pathway in NSCLC. Then, (PI3K) inhibitor
more » ... reased anticancer effects of Cucurbitacin I on NSCLC. In conclusion, the present results indicated that Cucurbitacin I inhibited cell growth of human NSCLC through PI3K/AKT/p70S6K signaling pathway.
doi:10.3892/mmr.2017.8141 pmid:29207097 fatcat:33pvdfoigzgqpn3n4t3ukq4xty
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Xueqiang Zhu, Hui Huang, Jun Zhang, Hao Liu, Rui Ao, Ming Xiao, Yuelei Wu. "The anticancer effects of Cucurbitacin I inhibited cell growth of human non‑small cell lung cancer through PI3K/AKT/p70S6K pathway." Molecular Medicine Reports (2017)