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The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma [article]

Tyler Alban, Matthew M Grabowski, Balint Otvos, Defne Bayik Watson, Ajay Zalavadia, Vlad Makarav, Katie M. Troike, Mary McGraw, Anja Rabljenovic, Adam Lauko, Chase K A Neumann, Gustavo Roversi (+16 others)
2022 bioRxiv   pre-print

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https://web.archive.org/web/20220606044049/https://www.biorxiv.org/content/biorxiv/early/2022/03/08/2022.03.07.483365.full.pdf

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While immunotherapies have shown durable responses for multiple tumors, their efficacy remains limited in some advanced cancers, including glioblastoma. This may be due to differences in the immune landscape, as the glioblastoma microenvironment strongly favors immunosuppressive myeloid cells, which are linked to an elevation in immune-suppressive cytokines, including macrophage migration inhibitory factor (MIF). We now find that a single-nucleotide polymorphism (SNP) rs755622 in the MIF
more » ... r associates with increased leukocyte infiltration in glioblastoma. Furthermore, we identified lactotransferrin expression as being associated with the rs755622 SNP, which could also be used as a biomarker for immune infiltrated tumors. These findings provide the first example in glioblastoma of a germline SNP that underlies differences in the immune microenvironment and identifies high lactotransferrin as a potential factor promoting immune activation.
doi:10.1101/2022.03.07.483365 fatcat:srwewpnrcbbanlkzxuhn2kgtaq
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Tyler Alban, Matthew M Grabowski, Balint Otvos, Defne Bayik Watson, Ajay Zalavadia, Vlad Makarav, Katie M. Troike, Mary McGraw, Anja Rabljenovic, Adam Lauko, Chase K A Neumann, Gustavo Roversi, Kristin Waite, Gino Cioffi, Nirav Patil, Thuy Tran, Kathleen McCortney, Alicia Steffens, Marcela Diaz, J. Mark Brown, Kathleen Egan, Craig Horbinski, Jill Barnholtz-sloan, Michael Vogelbaum, Richard Bucala, Timothy Chan, Manmeet Ahluwalia, Justin Lathia. "The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma." bioRxiv (2022)