Overview: Intertek Cantox has reexamined the safety and dosing guidelines of dietary supplements containing p-synephrine, a direct-acting sympathomimetic amine derived from the plant Citrus aurantium (bitter orange), alone and in combination with caffeine. It was concluded that as a single one-time dose, up to 70 mg p-synephrine alone or 40 mg in combination with 320 mg of caffeine is not likely to cause adverse effects. If taken as divided doses spaced out over the course of a day, 100 mg of

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... synephrine alone (e.g., 50 mg twice a day or 33 mg three times daily) or 70 mg in combination with 400 mg of caffeine is unlikely to be associated with adverse effects.