Review of the Safety Data Available on p-Synephrine, Caffeine, and p-Synephrine-Caffeine Containing Combination Products

Barry Lynch
2013 unpublished
Overview: Intertek Cantox has reexamined the safety and dosing guidelines of dietary supplements containing p-synephrine, a direct-acting sympathomimetic amine derived from the plant Citrus aurantium (bitter orange), alone and in combination with caffeine. It was concluded that as a single one-time dose, up to 70 mg p-synephrine alone or 40 mg in combination with 320 mg of caffeine is not likely to cause adverse effects. If taken as divided doses spaced out over the course of a day, 100 mg of
more » ... synephrine alone (e.g., 50 mg twice a day or 33 mg three times daily) or 70 mg in combination with 400 mg of caffeine is unlikely to be associated with adverse effects.