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Deletion of Irf3 and Irf7 Genes in Mice Results in Altered Interferon Pathway Activation and Granulocyte-Dominated Inflammatory Responses to Influenza A Infection
2016
Journal of Innate Immunity
strong increase of mortality associated with a massive influx of granulocytes in the lung and reduced activation of the adaptive immune response. Fig. 6. Quantification of IFN type I and type III protein levels in KO and WT mice infected with PR8M IAV. After intranasal infection of female mice at the age of 8-11 weeks (n = 5-8) with PBS or 2 × 10 5 FFU PR8M, BAL was collected at the indicated days and used for IFNA ( a ), IFNB1 ( b ) or IFNL2/3 (IL-28A/B; c ) detection by ELISA. Each sample was
doi:10.1159/000450705
pmid:27811478
fatcat:ephibb7k4revlbicc7f6qpjgbm