Silver nanoparticles synthesized using Tualang honey ameliorate seizures, locomotor activity, and memory function in KA-induced status epilepticus in male rats

Hidani Hasim, Sirajudeen Kuttulebbai Naina Mohamed Salam, Pasupuleti Visweswara Rao, Sangu Muthuraju, Mustapha Muzaimi, Mohd Asnizam Asari
2022 Biomedical Research and Therapy  
seizure was recorded. After 24 hours and five days of KA induction, an open field test (OFT) and a novel object recognition test (NORT) were performed before they were sacrificed. Results: THSN pre-treatment of KA-induced status epilepticus groups demonstrated an increment in latencies to the onset of the first generalized seizure and the number of line crossings in OFT, with a higher recognition index of NORT compared to the untreated KA-induced status epilepticus group. Conclusion: THSN could
more » ... have neuroprotective effects in ameliorating seizures, locomotor activity, and memory function after KA-induced status epilepticus in male rats.
doi:10.15419/bmrat.v9i9.766 fatcat:r6q3pcs2hjgalozqt7ybbgtn3y