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Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines
Molecular Cancer Therapeutics
Bovine lactoferricin (LfcinB) is a cationic, amphipathic peptide that is cytotoxic for human and rodent cancer cells. However, the mechanism by which LfcinB causes the death of cancer cells is not well understood. Here, we show that in vitro treatment with LfcinB rapidly induced apoptosis in several different human leukemia and carcinoma cell lines as determined by DNA fragmentation assays and phosphatidylserine headgroup inversion detected by Annexin V binding to the surface of cancer cells.doi:10.1158/1535-7163.mct-04-0077 pmid:15827335 fatcat:gc4fbjzzdjfmvmsszinop76aba