DELETION IN dbl DOMAIN OF bcr/abl GENE IN LEUKEMIA PATIENTS WITH Ph¢ CHROMOSOME ÄÅËÅÖÈÈ Â Ó×ÀÑÒÊÅ dbl ÃÅÍÀ bcr/abl Ó ÁÎËÜÍÛÕ ËÅÉÊÎÇOÌ Ñ ÍÀËÈ×ÈÅÌ Ph¢-ÕÐÎÌÎÑÎÌÛ

M Dybkov, G Telegeev, A Dubrovskaya, S Maliuta
2001 Experimental Oncology   unpublished
In some leukemia patients with Ph¢ chromosome the presence of deletions in the dbl domain of hybrid bcr/abl gene was shown. The possible influence of such genetic alterations on peculiarities of disease course is discussed. Ó íåêîòîðûõ áîëüíûõ ëåéêåìèåé ñ íàëè÷èåì Ph¢-õðîìîñîìû îáíàðóaeåíû äåëåöèè â dbl äîìåíå ãèáðèäíîãî ãåíà bcr/abl. Îáñóaeäàåòñÿ âîçìîaeíîå âëèÿíèå ïîäîáíûõ èçìåíåíèé íà îñîáåííîñòè òå÷åíèÿ çàáîëåâàíèÿ. Êëþ÷åâûå ñëîâà: äåëåöèè, ãåí bcr/abl, äîìåí dbl, Ph¢ õðîìîñîìà, ëåéêåìèÿ.
fatcat:tphyzbxzazckhkqnmfrafr3j2q