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EVOLUTIONARY CONSTRAINT NETWORKS IN LIGAND-BINDING DOMAINS: AN INFORMATION-THEORETIC APPROACH
Ligand-binding sites in homologous protein domains can diverge greatly during evolution. This poses a particularly interesting problem in those cases where the ligand-binding site is situated in, or close to, the domain core, or where ligand-docking induces dramatic conformational changes. These features are present in many receptors and enzymes; the hormone-binding domain of the nuclear receptors for steroids and retinoids, for example, exhibits both characteristics. It is therefore of greatdoi:10.1142/9789814447300_0009 fatcat:rmqg4zmbrbdyzjtk5xaig2z5fu