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The hippocampus is affected at an early stage in the development of Alzheimer's disease (AD). Using brain Magnetic Resonance (MR) images, we can investigate the effect of AD on the morphology of the hippocampus. Statistical shape models (SSM) are usually used to describe and model the hippocampal shape variations among the population. We use the shape variation from SSM as features to classify AD from normal control cases (NC). Conventional SSM uses principal component analysis (PCA) to computedoi:10.1117/12.877869 dblp:conf/miip/ShenBFMS11 fatcat:zbonq5sfenf7posu3myazjqz5e