Grignard-mediated reduction of 2,2,2-trichloro-1-arylethanones

Ali H. Essa, Reinner I. Lerrick, Eçe Çiftçi, Ross W. Harrington, Paul G. Waddell, William Clegg, Michael J. Hall
2015 Organic and biomolecular chemistry  
2,2,2-Trichloro-1-aryl-ethanones can be reduced by RMgX to the corresponding 2,2-dichloro-1-arylethen-1-olates and trapped with a range of electrophiles. In addition we demonstrate that 2,2-dichloro-1-arylethen-1-olates undergo counter-ion controlled Darzens condensations.
doi:10.1039/c5ob00541h pmid:25906144 fatcat:c25hnhmc6nfrtfua3gffae5uwe