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METHOD DEVELOPMENT AND VALIDATION OF DIFFERENCE UV SPECTROPHOTOMETRIC ESTIMATION OF LAFUTIDINE IN BULK AND PHARMACEUTICAL DOSAGE FORM
A simple, precise and sensitive UV spectrophotometric method has been developed for estimation of Lafutidine in bulk and pharmaceutical dosage form by difference spectrophotometric method. This method is based on principle that Lafutidine shows two different forms in acidic and basic medium. Lafutidine exhibited maximum and minimum absorbance at about 288nm and 264nm in acidic and basic solution. Beer's law was obeyed in range of 5-25µg/ml. The correlation coefficient was found to be 0.9980.Thefatcat:oceavdbio5eyhagdxfb7gjttsu