Reply:

M. Isabel Lucena, Carmen Martínez, Raúl J. Andrade, Elena García-Martín, Eugenia Ulzurrun, José A. G. Agúndez
2009 Hepatology  
We appreciate the comments of Leiro et al. on the role of the combined glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) null genotypes in determining the susceptibility to developing idiosyncratic drug-induced liver injury (DILI) as a general mechanism that occurs regardless of the type of drug involved. 1 These enzymes are predominantly expressed in the liver, and apart from being involved in drug metabolism, they modulate the byproducts of oxidative stress, an important common This letter was written on behalf
doi:10.1002/hep.22922 fatcat:jrvwtftvabbbri6mpwpxh2lx54