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The association between BPA exposure, DNA methylation, gene expression, and altered neurodevelopment in Zebrafish [article]

Paulina M. Ring, University Of Canterbury
2022

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Epigenetics plays a vital role in correct neurodevelopment. Chemical exposures such as bisphenol A (BPA) can disrupt epigenetic patterns in the brain and lead to altered neurodevelopment, with long lasting effects on gene expression and behaviour. This research project investigated the effects of BPA on DNA methylation and gene expression of neurodevelopmentally important genes as well as the DNA methyltransferase enzymes in Zebrafish. BPA exposure caused hatching delay and hatching number
more » ... ase in treated embryos, as well as an increase in mortality. DNA methylation changes were observed in one neurodevelopmental gene NTRK2a but not in the other genes analysed here. There were no significant gene expression level changes seen in DNMT3aa, NTF3, and SORT1a. While BPA had an effect on hatching rate and DNA methylation, BPA did not have an observable effect on gene expression within the scope of this research project.
doi:10.26021/13271 fatcat:fcqmw6imwffu3mgzfdfdt5umoa
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Paulina M. Ring, University Of Canterbury. "The association between BPA exposure, DNA methylation, gene expression, and altered neurodevelopment in Zebrafish." (2022)