The current study aims at developing formulations based on microemulsions for the transdermal patch of Baclofen. Castor oil was used in the oil phase, Tween-20 was used as a surfactant, propylene glycol(PG) worked as a cosurfactant, and water worked as an aqueous phase in the formation of microemulsions. Using Franz diffusion cells, in vitro permeation tests were conducted. At the conclusion of 8 hours, the in vitro permeation release of ME-3 was determined to be 88.79%, and baclofen

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... on was later put into the transdermal patch. The most effective composition was ME-3, which included dimethyl sulfoxide as a penetration enhancer, propylene glycol as a plasticizer, and carbopol 940 as a bio-adhesive polymer. The formulation with the best penetration enhancement exhibited a 39-fold increase and contained 0.1% DMSO. It was discovered that ME-3 Patch has a 97.67% in vitro permeation release rate. According to a study, baclofen may be produced into transdermal patches with an acceptable appearance and an appropriate drug release time of 4 hours. Keywords: (ME-)Microemulsion, HPMC, Transdermal patch, Baclofen, Carbopol- 940