WIT: integrated system for high-throughput genome sequence analysis and metabolic reconstruction

R. Overbeek
2000 Nucleic Acids Research  
The WIT (What Is There) (http://wit.mcs.anl.gov/WIT2/ ) system has been designed to support comparative analysis of sequenced genomes and to generate metabolic reconstructions based on chromosomal sequences and metabolic modules from the EMP/MPW family of databases. This system contains data derived from about 40 completed or nearly completed genomes. Sequence homologies, various ORFclustering algorithms, relative gene positions on the chromosome and placement of gene products in metabolic
more » ... ays (metabolic reconstruction) can be used for the assignment of gene functions and for development of overviews of genomes within WIT. The integration of a large number of phylogenetically diverse genomes in WIT facilitates the understanding of the physiology of different organisms.
doi:10.1093/nar/28.1.123 pmid:10592199 pmcid:PMC102471 fatcat:nb5kgeksafhsrilrgpgm7l3yfq