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Tight coordination of stem cell function by local and systemic signals is essential to preserve adult tissue homeostasis and organismal health. The vasculature is a prominent component of various stem cell niches 1-5. However, its role in intestinal homeostasis is largely unknown. Here, we uncover a previously unrecognised crosstalk between intestinal stem cells (ISCs) of the adult Drosophila midgut and the vasculature-like tracheal system 6, which is essential for regeneration of the injureddoi:10.1101/2021.01.10.426079 fatcat:yhsoqsimnbfl5mgx5nbwmhyq5m