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Randomized control trial of topical clonidine for treatment of painful diabetic neuropathy
2012
Pain
A length-dependent neuropathy with pain in the feet is a common complication of diabetes (painful diabetic neuropathy, PDN). It was hypothesized that pain may arise from sensitizedhyperactive cutaneous nociceptors, and that this abnormal signaling may be reduced by topical administration of the α 2 -adrenergic agonist, clonidine, to the painful area. This was a randomized, double-blind, placebo-controlled, parallel-group, multi-center trial. Nociceptor function was measured by determining the
doi:10.1016/j.pain.2012.04.014
pmid:22683276
pmcid:PMC3413770
fatcat:fitgc4so5fbrzlyx4kxnrjt6n4