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This rapid review summarizes the most up to date evidence about the risk factors for severe foodinduced allergic reactions. We searched three bibliographic databases for studies published between January 2010 and August 2021. We included 88 studies and synthesized the evidence narratively, undertaking metaanalysis where appropriate. Significant uncertainties remain with respect to the prediction of severe reactions, both anaphylaxis and/or severe anaphylaxis refractory to treatment. Priordoi:10.5167/uzh-224935 fatcat:z6dwve46zfdz3akpp475ieyl64