Cathecholamine and 5-hydroxytryptamine levels in ischemic brain. Influence of p-chlorophenylalanine

K M Welch, E Chabi, J Buckingham, B Bergin, V S Achar, J S Meyer
1977 Stroke  
CEREBRAL ISCHEMIA/Dodson et al. 341 microscopy. J Ultrastruct Res 26: 31-43, 1969 20. Reynolds ES: Use of lead citrate at high pH as an electron opaque stain in electron microscopy. J Cell Biol 17: 209-213, 1963 21. Miyakawa Y, Meyer JS, Ishihara N, et al: Effect of cerebrospinal fluid removal on cerebral blood flow and metabolism in the baboon: Influence of tyrosine infusion and cerebral embolism on cerebrospinal fluid pressure autoregulation. Stroke 8 (3): 346-351, 1977 22. Dodson RF, Aoyagi
more » ... , Hartmann A, et al: Acute cerebral infarction and hypotension: Ultrastructural study. J Neuropath Exp Neurol 33: 400-407, 1974 23. Sundt TM, Grant WC, Garcia JH, et al: Restoration of middle cerebral artery flow in experimental infarction. SUMMARY The effect of ischemia on catecholamine and 5hydroxytryptamine (S-HT) levels in brain cortex was examined in the gerbil stroke model. Unilateral common carotid artery occlusion produced bilateral decrease in cortical dopamine levels in gerbils both symptomatic and asymptomatic of cerebral ischemia. The 5-HT progressively decreased only in the occluded hemisphere of ischemic animals. In pehlorophenylalanine (PCPA)-treated gerbils, dopamine decreased only in the occluded hemisphere of symptomatic animals, but norepinephrine became decreased bilaterally compared with conby guest on
doi:10.1161/01.str.8.3.341 pmid:140480 fatcat:4ef72zfwbrgbxgwbov4ag64rvy