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Discovery of small protein complexes from PPI networks with size-specific supervised weighting
2014
BMC Systems Biology
The prediction of small complexes (consisting of two or three distinct proteins) is an important and challenging subtask in protein complex prediction from protein-protein interaction (PPI) networks. The prediction of small complexes is especially susceptible to noise (missing or spurious interactions) in the PPI network, while smaller groups of proteins are likelier to take on topological characteristics of real complexes by chance. We propose a two-stage approach, SSS and Extract, for
doi:10.1186/1752-0509-8-s5-s3
pmid:25559663
pmcid:PMC4305982
fatcat:7qgspney2jfb7cxypbccr6hw2q