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Striatal Potassium Channel Dysfunction in Huntington's Disease Transgenic Mice
Journal of Neurophysiology
Striatal potassium channel dysfunction in Huntington's disease transgenic mice. . Huntington's disease (HD) is a neurodegenerative disorder that mainly affects the projection neurons of the striatum and cerebral cortex. Genetic mouse models of HD have shown that neurons susceptible to the mutation exhibit morphological and electrophysiological dysfunctions before and during development of the behavioral phenotype. We used HD transgenic mouse models to examine inwardly and outwardly rectifying Kdoi:10.1152/jn.00791.2004 pmid:15625098 fatcat:pc6oagvborg2pa26whzc6x25me