AEBP1 is differentially expressed in various tumors. However, the correlation between AEBP1 and immune cell infiltration in gastric cancer remains unclear. Kaplan-Meier survival curves were used to evaluate the relationship between AEBP1 expression and overall survival and progression-free survival. The relationship between AEBP1 expression and infiltrating immune cells, and their corresponding gene marker sets was examined using the TIMER database.The expression of AEBP1 was lower in gastric

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... ncer (GC) tumor tissues than in normal tissues (P < 0.05). High AEBP1 gene expression and high levels of AEBP1 gene methylation were correlated with high-grade malignant tumor and old TNM stage. In addition, in gastric cancer, there was a positive correlation between AEBP1 expression and immune infiltrating cells, including neutrophils, CD8 + T cells, and CD4 + T cells, as well as immune-related genes, including CD2, CD3D, and CD3E. Methylation sites such as cg00009293, cg08495088, cg12955216, cg10480062, cg06852744 and cg12978582 were positively correlated with low expression of AEBP1. AEBP1 may be a potential tumor suppressor gene in GC and a potential novel therapeutic target and predictive biomarker for GC. AEBP1 likely plays an important role in immune cell infiltration.