Thalamic deactivation during early implicit sequence learning

Scott L. Rauch, Paul J. Whalen, Tim Curran, Sean McInerney, Stephan Heckers, Cary R. Savage
1998 NeuroReport  
865 PREVIOUS research has implicated the striatum in implicit sequence learning. However, imaging findings have been inconsistent with regard to activity within the thalamus during performance of such tasks. Contemporary models of cortico-striato-thalamic circuitry suggest opposing influences on thalamic activity; suppression of thalamic activity is mediated by the indirect pathway and enhancement is mediated by the direc t pathway. Using functional magnetic resonance imaging, we studied
more » ... y within human thalamus during early and late phases of an implicit sequence learning task known to reliably recruit the striatum. Significant deactivation (decreased signal relative to a baseline condition) was observed within the thalamus during early implicit learning. This finding is consistent with models of cortico-striato-thalamic function and specifically supports a profile of early 'thalamic gating' via the indirect pathway . NeuroRepor t9: 865-870
doi:10.1097/00001756-199803300-00019 pmid:9579681 fatcat:v3tuw5gcwzaa7cj44odlrtpmi4