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Drugs safety issues are now recognized as being factors generating the most reasons for drug withdrawals at various levels of development and at the post-approval stage. Among them cardiotoxicity remains the main reason, despite the substantial effort put into in vitro and in vivo testing, with the main focus put on hERG channel inhibition as the hypothesized surrogate of drug proarrhythmic potency. The large interest in the IKr current has resulted in the development of predictive tools anddoi:10.1186/2050-6511-13-6 pmid:22947121 pmcid:PMC3506270 fatcat:lwsy5surjzcu7f5ougyd375nvi