Clinical Evidence for Immunomodulatory Effects of Probiotic Bacteria

FM Ruemmele, D Bier, P Marteau, G Rechkemmer, R Bourdet-Sicard, WA Walker, O Goulet
2009 Journal of Pediatric Gastroenterology and Nutrition - JPGN  
Close, tightly orchestrated interactions between the intestinal epithelium and the mucosa-associated immune system are critical for normal intestinal absorptive and immunological functions. Recent data indicate that commensal intestinal microbiota represents a major modulator of intestinal homeostasis. This review analyzes the process of intestinal colonization and the interaction of microbiota with the intestinal epithelium and mucosal immune system, with special reference to the first years
more » ... extrauterine life. Dysregulation of the symbiotic interaction between intestinal microbiota and the mucosa may result in a pathological condition with potential clinical repercussions. Based on the concept that there is a beneficial and symbiotic relation between the host and endogen-
doi:10.1097/mpg.0b013e31817d80ca pmid:19179874 fatcat:qwjifrfmgzdndaogtc4enhtlai