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This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.doi:10.3390/vaccines9020097 pmid:33525396 pmcid:PMC7911542 fatcat:oii2ab7yyzd3tiezkc72mofb5e