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The elucidation of genes implicated in Mendelian forms of hypertension demonstrates rare variants with substantial effects are responsible, and often these genes lie within pathways managing sodium homeostasis. More recently with advances in affordable high-throughput genotyping strategies, multiple common genetic variants with modest effects on blood pressure (<1 mm Hg systolic) have been discovered in the population. In aggregate, these common variants explain <3% of the variance of blooddoi:10.1161/circresaha.112.300387 pmid:23661711 fatcat:wzeovigwobeypn6us4ltdszyny