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Network-based function prediction and interactomics: The case for metabolic enzymes
2011
Metabolic Engineering
As sequencing technologies increase in power, determining the functions of unknown proteins encoded by the DNA sequences so produced becomes a major challenge. Functional annotation is commonly done on the basis of amino-acid sequence similarity alone. Long after sequence similarity becomes undetectable by pair-wise comparison, profile-based identification of homologs can often succeed due to the conservation of position-specific patterns, important for a protein's three dimensional folding and
doi:10.1016/j.ymben.2010.07.001
pmid:20654726
fatcat:yn3ksrj2ore2rlmh34rvzbqeju