Correlation between activity of lupus nephritis and different ANA antibodies

Alaa Hemdan, Sahar Alsayed
2021 Sohag Medical Journal  
To detect the correlation between the activity of systemic lupus erythematosus especially lupus nephritis with ANA profile (anti-histone, anti-dsDNA, andnucleosome antibodies). Methods: Clinical and demographic data were analyzed statistically in 70 lupus nephritis patients from October 2018 to July 2019. We used serum test Euroline ANA profile (IgG)to detected the reactivity to a group of 19 autoantibodies. The correlation of the 3 autoantibodies (anti-dsDNA, anti-histone, and anti-nucleosome
more » ... nd anti-nucleosome antibodies)with nephritis was analyzed. Renal biopsies were studied by pathologists. The Immune complex deposition was recognized by immunohistochemistry stain. Results: Our study detected the correlation of anti-nucleosome,-histone, and -dsDNA antibodies in lupus nephritis diagnosis. Furthermore, our study suggests that we can predict the kidney affection and activity of lupus nephritis by the positive correlation between antinucleosome, -dsDNA, and -histone antibodies, which may make a major addition in the follow-up and treatment of lupus patients. Close reactivity with anti -nucleosome,-dsDNA, and -histone antibodies (3-positive antibodies) in SLE patients was highly related to the pathology of lupus nephritis. Three-pos patients of LN showed highly significant levels of these 3 antibodies manifested by more severe nephropathy and in needing more treatments than non three pos patients of lupus nephritis, which indicating three positive antibodies as a biomarker for lupus nephritis severity. Conclusions: ANA profile (IgG) especially the 3 autoantibodies (Anti-nucleosomehistone and -dsDNA antibodies ) may be used as indicators for severe kidney affection and activity in patients of SLE.
doi:10.21608/smj.2021.51715.1215 fatcat:2zshqlpw7fhofezwhvweker3by