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Structural basis for sigma-1 receptor ligand recognition
[article]
2018
bioRxiv
pre-print
The sigma-1 receptor is a poorly understood integral membrane protein expressed in most cells and tissues in the human body. It has been shown to modulate the activity of other membrane proteins such as ion channels and G protein-coupled receptors, and ligands targeting the sigma-1 receptor are currently in clinical trials for treatment of Alzheimer's disease, ischemic stroke, and neuropathic pain. Despite its importance, relatively little is known regarding sigma-1 receptor function at the
doi:10.1101/333765
fatcat:uy5t4ahslngwteade4633o62ym