A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is
The sigma-1 receptor is a poorly understood integral membrane protein expressed in most cells and tissues in the human body. It has been shown to modulate the activity of other membrane proteins such as ion channels and G protein-coupled receptors, and ligands targeting the sigma-1 receptor are currently in clinical trials for treatment of Alzheimer's disease, ischemic stroke, and neuropathic pain. Despite its importance, relatively little is known regarding sigma-1 receptor function at thedoi:10.1101/333765 fatcat:uy5t4ahslngwteade4633o62ym