Short Communication GRP78 expression in canine mammary tumors: association with malignancy

Joana De Oliveira, Cláudia Ribeiro, Fátima Gärtner
78-kDa glucose-regulated protein (GRP78) is over-expressed in human breast carcinomas. GRP78 expression was studied in 40 spontaneous canine mam-mary tumors and evaluated in relation to tumor histo-logical type, mode of growth, grade, lymph node me-tastases and distant metastases. All tumors exhibited GRP78 immunostaining. In the normal canine mam-mary gland, GRP78 was also expressed although not in all cases. In carcinomas GRP78 was detected in the cytoplasm in more than 50% of tumor cells in
more » ... of tumor cells in the vast majority of cases (87.5%). There was a significant association between the absence of squamous differentiation (P = 0.02) and GRP78 over-expression, but no association with other clinico-pathological features. GRP78 was often co-expressed with galectin-3 in canine mammary tumors (CMT).