New ultrasonographic screening method for oropharyngeal dysphagia: tissue Doppler imaging

Noriaki Manabe, Ken Haruma, Rui Nakato, Hiroaki Kusunoki, Tomoari Kamada, Jiro Hata
2018 American Journal of Physiology - Gastrointestinal and Liver Physiology  
36 Background: Ultrasound Tissue Doppler imaging (US-TDI) has been used to diagnose 37 regional wall motion (WM) abnormalities in coronary artery disease, but has not been 38 applied to oropharyngeal diseases. This study aimed first to validate an US-TDI method to 39 assess cervical esophageal (CE) WM, and secondly to use the method to evaluate CE WM 40 in patients with oropharyngeal dysphagia (OD). 41 Methods: First, we enrolled 22 healthy men (mean age: 59.7 years) who all underwent both 42
more » ... -TDI and videofluoroscopy (VF) and then esophageal high-resolution manometry 43 (HRM) in the same week. We evaluated the reproducibility of the US-TDI, and the 44 relationship between US-TDI and other modalities (VF and HRM). Second, we enrolled 56 45 mild OD patients (mean age: 58.0 years) and age-and sex-matched healthy controls. 46 Difference in CE WM between these groups was evaluated by US-TDI. 47 Results: All healthy subjects underwent US-TDI, VF, and HRM successfully, with a 48 sufficiently high reproducibility coefficient for this method, and significant correlation 49 between US-TDI and VF/HRM parameters. US-TDI showed mean time to open CE wall 50 and mean velocity of CE wall opening significantly differed between patients and healthy 51 controls (P<0.01). 52 Conclusion: We have developed a US-TDI method for easily assessing CE WM in daily 53 practice, and also found significant differences in CE WM between mild OD patients and 54 healthy controls. 55 56
doi:10.1152/ajpgi.00019.2017 pmid:28864498 fatcat:av7lx5opnzekdiaobg3vw5d7vi