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Purpose: To assess percutaneous nephrolithotomy (PCNL)-induced kidney tubular damage and the associated factors. Materials and Methods: One hundred and eight patients who have undergone PCNL from were recruited in this study. Urinary level of 2-microglobulin (U2MG) was measured on the day before the operation as well as on the 1 st and 7 th post PCNL days. Percutaneous nephrolithotomy was performed using standard method. Patients' demographic and peri-operative data were collected to evaluatefatcat:7ogr6zhfprhtbikgzmqoh76bl4