Development and evaluation of a time-resolved near-infrared fluorescence finite element model

Qun Zhu, Frederic Leblond, Fadi El-Ghussein, Brian W. Pogue, Hamid Dehghani, Bruce J. Tromberg, Arjun G. Yodh, Mamoru Tamura, Eva M. Sevick-Muraca, Robert R. Alfano
2011 Optical Tomography and Spectroscopy of Tissue IX  
In this work a generalization of the approach allowing time-domain (TD) excitation and fluorescence data to be generated using a finite element model (FEM) is introduced. This new functionality allows simulation of temporal pointspread functions (TPSF) for a heterogeneous scattering and absorbing media of arbitrary geometry. In the first part of this paper, the approach used to develop a computationally efficient model for solving the time-dependent diffusion equation for excitation and
more » ... itation and fluorescence data is presented. In the second part, a detailed theoretical evaluation of the method is given by comparing the developed FEM simulations with analytical and Monte Carlo data. The total fluence (intensity data), shows qualitative match whereas meantime of flight is almost identical among the three models for both excitation and emission data. The results show that the model is reliable and warrants its use for future TD applications where diffusion modelling can be used.
doi:10.1117/12.873741 fatcat:ubxxykhszjh25hqfqkyj7bhveu