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AbstractIn many situations, the gene expression signature is a unique marker of the biological state. We study the modification of the gene expression distribution function when the biological state of a system experiences a change. This change may be the result of a selective pressure, as in the Long Term Evolution Experiment with E. Coli populations, or the progression to Alzheimer disease in aged brains, or the progression from a normal tissue to the cancer state. The first two cases seem todoi:10.1038/s41598-021-87764-0 pmid:33875699 fatcat:np2paqa765dipc2wsol6tk7lty