Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data

Jean Logan, Joanna S. Fowler, Nora D. Volkow, Gene-Jack Wang, Yu-Shin Ding, David L. Alexoff
1996 Journal of Cerebral Blood Flow and Metabolism  
Ch~rnisrry rind 'Medicrrl Depnrrrnc2nf.c. LIrooLhtrrzc~n iVrrfr:i::~rl Liihortrrory. IJpron,Ye\\ York. [I.S.A. Summary: The distribution volume ratio (DVR), which is a linear function of receptor availability, 1s widely used as a model parameter in imaging studies. The D V R cor:.esponds to the ratlo of the DV of a receptor-containing region to a nonreceptor region and generally requires the measurement of an arterial input function. Here we propose a graphical method for determining the IIVR
more » ... at does not require blood sampling. This method uses data from a nonreceptor region with an average tissue-to-
doi:10.1097/00004647-199609000-00008 pmid:8784228 fatcat:mcqhjpic6rdxjcbpgf23em4on4