Purpose: To report unprompted closure of spontaneous macular hole secondary to inadvertent subfoveal perfluorocarbon after vitrectomy surgery.Patients& Methods: We present a case of a retained large single subfoveal PFCL droplet following vitrectomy and silicone oil injection for subtotal rhegmatogenous retinal detachment (RRD) that showed spontaneous release 4 weeks postoperatively, with subsequent development of full thickness macular hole (FTMH) which completely closed later on after

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... oil removal without internal limiting membrane peeling.Results: Marvelous anatomic and visual improvement after spontaneous closure of MH.Discussion: Few complications have been associated with use of PFCLs. The most common is postoperative residual PFCL in vitreous cavity or in the anterior chamber. Subretinal retention of PFCL has been reported and it has the most significant ocular toxicity but spontaneous release of subfoveal PFCL without surgical interference has rarely been reported.Conclusion: Different behaviors of subfoveal PFC droplets may occur.