In this paper, we design a cellular automata (CA)based ROI (region of interest) image encryption system that can effectively reduce computational cost and maintain an appropriate level of security. The proposed image encryption system obtains a cryptographic image through three steps. First, a region of interest with high importance is extracted from the entire image using deep learning. We use the YOLO (You Only Look Once) algorithm to extract the ROI from a given original image. Next, the

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... cted ROI is encrypted using the Chen system, a chaotic-based function with high security. Finally, the execution time is effectively reduced by encrypting the entire image using a hardware-friendly CA. The safety of the proposed encryption system is verified through various statistical experiment results and analyses.