THE RENIN-ANGIOTENSIN SYSTEM (RAS) is well recognized for its key role in blood pressure, fluid homeostasis, vasoconstriction, hormone secretion, kidney function, and cellular growth. However, new roles for ANG II are being discovered, especially as it relates to how the RAS modulates immune cells. Indeed, inflammatory cells are equipped with all the components of the RAS and can produce ANG II. The ANG II receptor AT 1A is expressed in a variety of splenocyte populations, including T cells,

more »

... rophages, and B cells. In addition, AT 1 receptors are expressed in human circulating leukocytes, including polymorphonuclear leukocytes, monocytes, and B and T lymphocytes (10, 15). These discoveries have led to studies that are documenting a central role for the RAS in the control of the immune response.